Erich Harnack (1852-1915) and a short history of apomorphine.

نویسندگان

  • Pille Taba
  • Andrew Lees
  • Gerald Stern
چکیده

Apomorphine, now established as an efficacious therapy for refractory motor fluctuations in levodopa-treated Parkinson's disease, has a long and chequered history in medical and veterinary therapeutics. The preclinical in vivo pharmacological effects of apomorphine were first studied about 150 years ago following which the drug was introduced for the treatment of behavioural vices in domesticated animals. Erich Harnack's early pharmacological studies in Dorpat (now Tartu, Estonia), where he belonged to the pharmacological dynasty of Buchheim and Schmiedeberg, are of particular historical significance as he emphasised that while apomorphine had potent emetic effects, the drug also had complex effects on the central nervous system.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Jules-Auguste Soury (1842-1915): A Centennial Call to Mind.

Jules-Auguste Soury (1842-1915), a Parisian theorist and historian of science, was the author of 'The Central Nervous System', one of the most comprehensive and original accounts, until 1900, of the history of brain research. A contemporary of Jules Déjerine (1849-1917), Santiago Ramón y Cajal (1852-1934), and other pioneers of neurology, with whom he maintained contact, Soury is a rare case of...

متن کامل

A boundary Harnack principle in twisted Hölder domains

The boundary Harnack principle for the ratio of positive harmonic functions is shown to hold in twisted Hölder domains of order α for α ∈ (1/2, 1]. For each α ∈ (0, 1/2), there exists a twisted Hölder domain of order α for which the boundary Harnack principle fails. Extensions are given to L-harmonic functions for uniformly elliptic operators L in divergence form. Short title: Boundary Harnack ...

متن کامل

History of experimental psychology from an Estonian perspective.

A short review of the development of experimental psychology from an Estonian perspective is presented. The first rector after the reopening of the University of Dorpat (Tartu) in 1802, Georg Friedrich Parrot (1767-1852) was interested in optical phenomena which he attempted to explain by introducing the concept of unconscious inferences, anticipating a similar theory proposed by Herman von Hel...

متن کامل

An Analysis of the Signs of Growth and Decay in the Characters of Fereydoun and Zahhak from the Viewpoint of Erich Fromm

Literary texts are the product of individual unconscious psyche and collective consciousness. In Iranian mythology, Fereydoun and Zahhak are symbols of good and evil. This research is an attempt to demonstrate aspects of growth and decay according to Erich Fromm’s theories. It aims at finding aspects of growth (love of life, love of humanity, freedom from the archetypal Mother) and contra...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • European neurology

دوره 69 6  شماره 

صفحات  -

تاریخ انتشار 2013